- Episode 1 Amanda Peet, Tom Dreesen
- Episode 2 Jeff Goldblum, George Miller
- Episode 3 Drea de Matteo, Sarah Vowell, The Doves
- Episode 4 Peter Jennings, John Witherspoon
- Episode 5 John McEnroe, Piper Perabo, Queens of the Stone Age
- Episode 6 Jennifer Esposito, Marianne Faithful
- Episode 7 Bill Clinton, Nanci Griffith
- Episode 8 Regis Philbin, Linda Thompson
- Episode 9 Megan Mullally, Rich Hall
- Episode 10 Bruce Willis, Eve
- Episode 11 Jack Hanna, Tom Cavanagh, Civil War Reenactment
- Episode 12 Reese Witherspoon, Juan Montoya, India.Arie
- Episode 13 Rose McGowan, Phillipe Petit
- Episode 14 Lauren Graham, Colin Quinn
- Episode 15 Patricia Heaton, Murray Walker
- Episode 16 David Schwimmer, Avril Lavigne
- Episode 17 Anthony LaPaglia, Effie Nielson, Clinic
- Episode 18 Edward Norton, John Mayer
- Episode 19 David Arquette, Todd Lynn
- Episode 20 Jennifer Love Hewitt, Tom Petty and The Heartbreakers
- Episode 21 John McCain, David Sedaris
- Episode 22 Charles Barkley, Franco Zeffirelli, Nitty Gritty Dirt Band
- Episode 23 Michelle Pfeiffer, Bon Jovi
- Episode 24 Johnny Knoxville, Ron White
- Episode 25 Debra Messing, Pink
- Episode 26 Thandie Newton, Faith Hill
- Episode 27 Rudolph Giuliani, Naomi Watts
- Episode 28 Samuel L. Jackson, Santana & Michelle Branch
- Episode 29 P. Diddy, Eddie Brill
- Episode 30 Bonnie Hunt, Christina Aquilera
- Episode 31 Salma Hayek, Tori Amos
- Episode 32 Warren Zevon
- Episode 33 Jerry Seinfeld, Foo Fighters
- Episode 34 Don Rickles, Jim Gaffigan
- Episode 35 Stupid Human Tricks, Sean Hayes, Willie Nelson & Ryan Adams
- Episode 36 Julianne Moore, Grant Paulsen, Blind Boys of Alabama
- Episode 37 Kid Inventors, Tom Brokaw, The Wallflowers
- Episode 38 Brittany Murphy, Al Lubel
- Episode 39 Robin Williams, Emily Proctor
- Episode 40 Kelly Ripa, Emmitt Smith, Missy Elliott
- Episode 41 Barbara Walters, Joe Pantoliano
- Episode 42 Maggie Gyllenhaal, Pearl Jam
- Episode 43 Al Gore, Pearl Jam
- Episode 44 Kevin James, matchbox 20
- Episode 45 Shania Twain, Cristiano da Matta
- Episode 46 Adam Sandler, Pussycat Dolls
- Episode 47 Ice Cube, Cast of Hairspray
- Episode 48 Harry Connick Jr., Larry Miller
- Episode 49 Stupid Pet Tricks, Lisa Kudrow, Audioslave
- Episode 50 George Clooney, Jack Hanna
- Episode 51 Ray Romano, Jurassic 5
- Episode 52 Amy Sedaris, The Strokes
- Episode 53 Liza Minnelli, Jann Karam
- Episode 54 Jennifer Lopez, Sum 41
- Episode 55 Jason Alexander, Ryan Adams
- Episode 56 Nia Vardalos, Barry Sonnenfeld
- Episode 57 Allison Janney, Martin Scorsese
- Episode 58 Natasha Richardson, Mike Birbiglia, David Gray
- Episode 59 Catherine Zeta-Jones, Coldplay
- Episode 60 Drew Barrymore, Rod Stewart
- Episode 61 Denzel Washington, Daniel Bouloud
- Episode 62 Tom Hanks, Phish
- Episode 63 Liv Tyler, Jay Thomas, Darlene Love
- Episode 64 Ashton Kutcher, Jason Kidd
- Episode 65 Isabella Rossellini, Mort Sahl
- Episode 66 Michael Caine, George Foreman
- Episode 67 Richard Gere, Chris Elliott
- Episode 68 Merv Griffin, Interpol
- Episode 69 Renee Zellweger, Chuck Barris
- Episode 70 Andy Richter, Rich Hall
- Episode 71 Jimmy Kimmel, Simon Baker
- Episode 72 Claire Danes, Bob Sarlatte
- Episode 73 Sandra Bullock, Marv Albert
- Episode 74 George Clooney, Soundtrack of Our Lives
- Episode 75 Joan Rivers, Kathleen Edwards
- Episode 76 Simon Cowell, Topher Grace, Vienna Teng
- Episode 77 Regis Philbin, John C. Reilly
- Episode 78 Tina Fey, Jonathan Ames, Johnny Marr & The Healers
- Episode 79 Ellen DeGeneres, Zwan
- Episode 80 Bonnie Hunt, John Witherspoon
- Episode 81 Show #1944Kate Hudson, Jack Hanna
- Episode 82 Matthew McConaughey, John Gruden, The Roots
- Episode 83 Kelsey Grammer, Michael Tong, B.B. King and Shemeika Copeland
- Episode 84 Stupid Pet Tricks, Tom Brokaw, The Pretenders
- Episode 85 Brendan Fraser, Kids in The Hall, Bonnie Raitt, Keb' Mo, Kim Wilson
- Episode 86 Matthew Broderick, Tony Bennett & k.d. Lang
- Episode 87 Amy Brennamen, Nate Erwin, Vince Gill
- Episode 88 Queen Latifah, Colin Quinn, Lou Reed
- Episode 89 Kid Scientists, Kurt Russell
- Episode 90 Kate Winslet, Dennis Regan, Rufus Wainwright
- Episode 91 Dr. Phil, Beck
- Episode 92 Vince Vaughn, Sarah Vowel, Beck
- Episode 93 Kevin Spacey, Reggie Miller
- Episode 94 Champion Turkey Callers, Marg Helgenberger, The Flaming Lips
- Episode 95 Jeff Daniels, Lynne Cox, Steven Wright
- Episode 96 Steve Martin, Foo Fighters
- Episode 97 Stupid Human Tricks, Sharon Osborne, Norah Jones
- Episode 98 Bruce Willis, Dan Rather, Carmen Electra, Brian Kiley
- Episode 99 John McEnroe, Tom Arnold, Eric Ripert, Todd Barry, Jason Mras
- Episode 100 Regis Philbin, Charles Grodin, Susan Lucci, Greg Giraldo, Kathleen Edwards
- Episode 101 Whoopi Goldberg, Jessica Lange, Dave Chappelle, Andy Vistola, Ben Harper
- Episode 102 Vince Vaughn, Rosie Perez, Geri Halliwell, Dwayne Kennedy, Paul Simon
- Episode 103 Elvis Costello, Kim Cattrell, Eddie Izzard, Mitch Hedberg
- Episode 104 Will Ferrell, Chris Rock, Crispin Glover, Jake Johannsen, American Hi-Fi
- Episode 105 Megan Mullally, Molly Shannon, Isaac Mizrahi, Bonnie McFarlane
- Episode 106 Brad Garrett, Cuba Gooding Jr., Julie Bowen, Reggie McFadden, Lyle Lovett
- Episode 107 Tom Dreesen, Kiefer Sutherland, Frank Gershin, Suzanne Westenhoefer, The Music
- Episode 108 Bonnie Hunt, Carson Daley, Eddie Griffin, Ron Beth-Israel, Fabolous
- Episode 109 Paul Schaffer, Bob Dole, Connie Nielsen, Jeff Foxworthy, Cat Power
- Episode 110 Bill Cosby, Andrew Firestone, Clark Tery, Sofia Vergara, The DA
- Episode 111 Luke Wilson, Kelly Preston, Taye Diggs, Hilary Burton, Seether
- Episode 112 Billy Crystal, Michael Barimo
- Episode 113 Colin Farrell, Rosanne Cash
- Episode 114 Helen Hunt, Jeremy Suarez, Cory Branan
- Episode 115 High-Jumping Dogs, Vin Diesel, Bo Diddley
- Episode 116 Hilary Swank, Jimmie Walker
- Episode 117 Adam Sandler, The Folksmen
- Episode 118 Lisa Marie Presley, Jamie Kennedy
- Episode 119 Jane Krakowski, Jim Boeheim, Pete Yorn
- Episode 120 Tom Brokaw, Tom Russell & Nanci Griffith
- Episode 121 Michael Douglas, Todd Rundgren
- Episode 122 Anthony LaPaglia, Brian Regan, The Exies
- Episode 123 Ashton Kutcher, Jack Hanna
- Episode 124 Ellen DeGeneres, John Malkovich
- Episode 125 Charlize Theron, Sue Johanson, Minus 5 with Wilco
- Episode 126 Bernie Mac, Amanda Peet
- Episode 127 Halle Berry, Don Rickles
- Episode 128 Kelly Rippa, Good Charlotte
- Episode 129 Stupid Human Tricks, Hugh Jackson, Kelly Clarkson
- Episode 130 David Hyde Pierce, Rube Goldberg Contest Winners, Ziggy Marley
- Episode 131 Megan Mullally, Marilyn Manson
- Episode 132 Albert Brooks, Jeffery Ross, The Libertines
- Episode 133 Stupid Pet Tricks, Kevin James, Jenna Morasca
- Episode 134 David Williams & Ronald Young, Jada Pinkett Smith, The Jayhawks
- Episode 135 Sean Hayes, Eric Ripert, Avril Lavigne
- Episode 136 Rene Zellweger, Jack Johnson
- Episode 137 John Goodman, D.H. Hughley, NAS with Alicia Keys
- Episode 138 Mark Wahlberg, Jesse James, the Sounds
- Episode 139 Jim Carrey, Chevelle
- Episode 140 Regis Philbin, 3 Doors Down
- Episode 141 Antonio Banderas, Heidi Klum, Liam Lynch
- Episode 142 Peter Krause, Jim Gaffigan, Widespread Panic
- Episode 143 Adrien Brody, Gil de Ferran, John Mellencamp
- Episode 144 Alec Baldwin, Tom Dreesen
- Episode 145 Seth Green, Amy Sedaris, Lucinda Williams
- Episode 146 Barbara Walters, Tanya Streeter
- Episode 147 Tom Arnold, Darrell Hammond, Karolina Kurkova, Eddie Brill, Train
- Episode 148 Juliette Binoche, Joe Queenan, Blur
- Episode 149 Bruce Willis, Chris Moneymaker
- Episode 150 Lauren Graham, Marv Albert, Bright Eyes
- Episode 151 Harrison Ford, Annie Lennox
- Episode 152 Tom Green, Jolene Blalock, Scott Stevens, Isaac Britty, Damien Rice
- Episode 153 Hilary Clinton, Emmylou Harris
- Episode 154 Rob Reiner, Paul Teutul Sr. & Jr., The New Pornographers
- Episode 155 Johnny Depp, Christine Todd Whitman, B.B. King
- Episode 156 Sarah Jessica Parker, The Dead
- Episode 157 Kelsey Grammer, Treat Williams, James Earl Jones, Jamie Lynn-Sigler, Kathleen Madigan, Jesse Malin
- Episode 158 Demi Moore, Verbana
- Episode 159 Drew Barrymore, Simon Cowell
- Episode 160 Lucy Liu, Avigayil Wardein, Nick Cave and The Bad Seeds
- Episode 161 Piedmont Bird Callers, Luke Wilson, The Yeah Yeah Yeahs
- Episode 162 Jimmy Fallon, Kristanna Loken, Dax, Chloe Sevigny, Bill Scheft, Rufus Wainwright
- Episode 163 Lisa Marie Presley, Ryan Pinkston
- Episode 164 Allison Janney, Nigella Lawson, Howard Tate
- Episode 165 Barry Zito, Mandy Moore, Grandaddy
- Episode 166 Ari Fleischer, Beyonce Knowles
- Episode 167 Jeff Bridges, Alan Harvey, Joseph Arthur
- Episode 168 Aron Ralston, Tobey Maguire
- Episode 169 National Hollerin' Champions, Kristin Davis, Jane's Addiction
- Episode 170 Joaquin Phoenix, Blues Traveler
- Episode 171 Sylvester Stallone, Ben Curtis
- Episode 172 Denis Leary, Queens of the Stone Age
- Episode 173 Jesse Grabow, Jason Biggs, Robert C. Nichol
- Episode 174 Eugene Levy, Eels
- Episode 175 Seann William Scott, Jonathan Ames, Fountains of Wayne
- Episode 176 Melanie Griffith, Pamela Reed
- Episode 177 Naomi Watts, Jeff Stilson, O.A.R.
- Episode 178 Kate Hudson, Cast of Camp
- Episode 179 Colin Farrell, Robert Randolph & The Family Band
- Episode 180 Samuel L. Jackson, Rick Reilly, Pharrell with Clipse
- Episode 181 Brittany Murphy, Carey Hart, Dashboard Confessional
- Episode 182 David Duchovny, Brett Butler, The New Amsterdams
- Episode 183 Chris Rock, The Star Spangles
- Episode 184 Bill Murray, Pete Sampras
- Episode 185 David Spade, Bob Sarlatte, Maroon 5
- Episode 186 Tony Hawk, John McEnroe, Rooney
- Episode 187 Bonnie Hunt, Don Gavin
Late Show with David Letterman - Season 10
Runtime: 63:60 minutes
Quality: HD
First air date: Aug 30, 1993
Last air date: May 20, 2015
Episode: 4252 Episode
Season: 22 Season
IMDb: 4.701
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